BC Mental Health and Addictions Research Institute

Publications - William Honer

2006/07 to 2010/11

Vila-Rodriguez, F., Honer, W. G., Innis, S. M., Wellington, C. L., & Beasley, C. L. (2011). ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype. Journal of Psychiatry & Neuroscience : JPN, 36(1), 47-55.

Torres, I. J., DeFreitas, V. G., DeFreitas, C. M., Kauer-Sant'Anna, M., Bond, D. J., Honer, W. G., Lam, R.W., & Yatham, L. N. (2010). Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode. The Journal of Clinical Psychiatry, 71(9), 1234-1242.

Smith, G.N., MacEwan, G.W., Kopala, Lang, D.J., Barr, A.M., Honer, W.G., Ehmann, T.S., Good, K., Thornton, A.E., & Neilson, H. (2010) Prenatal tobacco exposure in first-episode psychosis. Schizophrenia Research, 119(1-3), 271–272.

Procyshyn, R. M., Honer, W. G., Wu, T. K., Ko, R. W., McIsaac, S. A., Young, A. H., Johnson, J.L., & Barr, A. M. (2010). Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: A review of medication profiles in 435 canadian outpatients. The Journal of Clinical Psychiatry, 71(5), 566-573.

Procyshyn, R. M., Barr, A. M., Flynn, S., Schenk, C., Ganesan, S., & Honer, W. G. (2010). Long-acting injectable risperidone in treatment refractory patients: A 14-week open-label pilot study. Schizophrenia Research, 123(2-3), 273-275.

Procyshyn, R. M., Barr, A. M., Brickell, T., & Honer, W. G. (2010). Medication errors in psychiatry: A comprehensive review. CNS Drugs, 24(7), 595-609.

Pajonk, F. G., Wobrock, T., Gruber, O., Scherk, H., Berner, D., Kaizl, I., Kierer, A., Müller, S., Oest, M., Meyer, T., Backens, M., Schneider-Axmann, T., Thornton, A.E., Honer, W.G., & Falkai, P. (2010). Hippocampal plasticity in response to exercise in schizophrenia. Archives of General Psychiatry, 67(2), 133-143.

Hunter, M. J., Hippman, C., Honer, W. G., & Austin, J. C. (2010). Genetic counseling for schizophrenia: A review of referrals to a provincial medical genetics program from 1968 to 2007. American Journal of Medical Genetics.Part A, 152A(1), 147-152.

Chen, E. Y., Hui, C. L., Lam, M. M., Chiu, C. P., Law, C. W., Chung, D. W., Tso, S., Pang, E.P., Chan, K.T., Wong, Y.C., Mo, F.Y., Chan, K.P., Yao, T.J., Hung, S.F., & Honer, W. G. (2010). Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: Randomised controlled trial. BMJ (Clinical Research Ed.), 341, c4024.

Boyda, H. N., Tse, L., Procyshyn, R. M., Honer, W. G., & Barr, A. M. (2010). Preclinical models of antipsychotic drug-induced metabolic side effects. Trends in Pharmacological Sciences, 31(10), 484-497.

Barr, A. M., Honer, W. G., Johnson, J. L., Wu, T. K., & Procyshyn, R. M. (2010). A comparison of antipsychotic drug-defined daily doses versus chlorpromazine equivalent doses in patients with or without extrapyramidal motor symptoms. Journal of Clinical Psychopharmacology, 30(6), 741-743.

Barakauskas, V. E., Ypsilanti, A. R., Barr, A. M., Innis, S. M., Honer, W. G., & Beasley, C. L. (2010). Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34(4), 669-673.

Wang, L., Metzak, P. D., Honer, W. G., & Woodward, T. S. (2010). Impaired efficiency of functional networks underlying episodic memory-for-context in schizophrenia. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 30(39), 13171-13179.

Barakauskas, V. E., Beasley, C. L., Barr, A. M., Ypsilanti, A. R., Li, H. Y., Thornton, A. E., Wong, H., Rosokija, G., Mann, J.J., Mancevski, B., Jakovski, Z., Davceva, N., Illevski, B., Dwork, A.J., Falkai, P., & Honer, W. G. (2010). A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 35(5), 1226-1238.

Lecomte, T., Mueser, K.T., MacEwan, G.W., Laferriere-Simard, M.C., Thornton, A.E., Buchanan, T., Goldner, E., Brink, J., Ehmann, T.S., Lang, D., Kang, S., Barr, A.M., & Honer, W.G. (2010). Profiles of individuals seeking psychiatric help for psychotic symptoms linked to methamphetamine abuse – Baseline results from the MAPS (methamphetamine and psychosis study) Mental Health Subst Abuse, 3, 168-181.

Procyshyn, R. M., Honer, W. G., & Barr, A. M. (2009). Do serum lipids predict response to clozapine treatment? Journal of Psychiatry & Neuroscience : JPN, 34(2), 168.

Smith, G.N., Wong, H., MacEwan, G.W., Kopala, L.C., Ehmann, T.S., Thornton, A.E., Lang, D.J., Barr, A.M., Procyshyn, R., Austin, J.C., Flynn, S.W., & Honer, W.G. (2009). Predictors of starting to smoke cigarettes in patients with first-episode psychosis. Schizophrenia Research, 108(1-3), 258-264.

Mukaetova-Ladinska, E. B., Xuereb, J. H., Garcia-Sierra, F., Hurt, J., Gertz, H. J., Hills, R., Brayne, C., Huppert, F.A., Paykel, E.S., McGee, M.A., Jakes, R., Honer, W.G., Harrington, C.R., & Wischik, C. M. (2009). Lewy body variant of alzheimer's disease: Selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe. The Scientific World Journal, 9, 1463-1475.

Honer, W. G., Procyshyn, R. M., Chen, E. Y., MacEwan, G. W., & Barr, A. M. (2009). A translational research approach to poor treatment response in patients with schizophrenia: Clozapine-antipsychotic polypharmacy. Journal of Psychiatry & Neuroscience : JPN, 34(6), 433-442.

Hippman, C., Oberlander, T. F., Honer, W. G., Misri, S., & Austin, J. C. (2009). Depression during pregnancy: The potential impact of increased risk for fetal aneuploidy on maternal mood. Clinical Genetics, 75(1), 30-36.

Beasley, C. L., Dwork, A. J., Rosoklija, G., Mann, J.J., Mancevski, B., Jakovski, Z., Davceva, N., Tait, A.R., Straus, S.K., & Honer, W.G. (2009). Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia. Schizophr Res., 109(1-3), 159-66.

Parlapani, E., Schmitt, A., Erdmann, A., Bernstein, H-G., Breunig, B., Gruber, O., Petroianu, G., von Willmsdorf, M., Schneider-Axmann, T., Honer, W.G., & Falkai, P. (2009). Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia. Brain Res 1301, 126-134.

Voineskos, A. N., de Luca, V., Bulgin, N. L., van Adrichem, Q., Shaikh, S., Lang, D. J., Honer, W.G., & Kennedy, J. L. (2008). A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia. Psychiatric Genetics, 18(3), 143-146.

Tepest, R., Vogeley, K., Viebahn, B., Schneider-Axmann, T., Honer, W. G., & Falkai, P. (2008). Automated gray level index measurements reveal only minor cytoarchitectonic changes of brodmann area 9 in schizophrenia. Psychiatry Research, 163(2), 183-192.

Ebner, F., Tepest, R., Dani, I., Pfeiffer, U., Schulze, T. G., Rietschel, M., Maier, W., Träber, F., Block, W., Schild, H.H., Wagner, M., Steinmetz, H., Gaebel, W., Honer, W.G., Schneider-Axmann, T., & Falkai, P. (2008). The hippocampus in families with schizophrenia in relation to obstetric complications. Schizophrenia Research, 104(1-3), 71-78.

Downes, E. C., Robson, J., Grailly, E., Abdel-All, Z., Xuereb, J., Brayne, C., Holland, A., Honer, W.G., & Mukaetova-Ladinska, E. B. (2008). Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly down syndrome individuals. Neuropathology and Applied Neurobiology, 34(1), 12-22.

Cai, F., Chen, B., Zhou, W., Zis, O., Liu, S., Holt, R. A., Honer, W.G., & Song, W. (2008). SP1 regulates a human SNAP-25 gene expression. Journal of Neurochemistry, 105(2), 512-523.

Barr, A. M., Procyshyn, R. M., Hui, P., Johnson, J. L., & Honer, W. G. (2008). Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatment. Schizophrenia Research, 100(1-3), 252-260

Wobrock, T., Kamer, T., Roy, A., Vogeley, K., Schneider-Axmann, T., Wagner, M., Maier,W., Rietschel, M., Schulze, T.G., Scherk, H., Schild, H.H., Block, W., Träber, F., Tepest, R., Honer, W.G. & Falkai, P. (2008). Reduction of the internal capsule in families affected with schizophrenia. Biological Psychiatry, 63(1), 65-71.

Barr, A. M., Fish, K. N., Markou, A., & Honer, W. G. (2008). Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins. The European Journal of Neuroscience, 27(10), 2568-2574.

Austin, J.C., & Honer, W.G. (2008). Psychiatric genetic counselling for parents of individuals affected with psychotic disorders: a pilot study. Early Intervention, 2, 80-89.

Voineskos, A.N., Lang, D.J., Zai, G., Bulgin, N., Shaikh, S., Su, W., Kopala, L.C., MacEwan, G.W., Thornton, A.E., Smith, G.N., Austin, J.C., Honer, W.G., & Kennedy, J.L. (2008). MAG gene variation and cortical gray matter volume in first episode schizophrenia. Brain Imaging & Behavior. Vol. 2(2): 117-122.        

Thornton, A. E., Boudreau, V. G., Griffiths, S. Y., Woodward, T. S., Fawkes-Kirby, T., & Honer, W. G. (2007). The impact of monetary reward on memory in schizophrenia spectrum disorder. Neuropsychology, 21(5), 631-645.

Procyshyn, R. M., Wasan, K. M., Thornton, A. E., Barr, A. M., Chen, E. Y., Pomarol-Clotet, E., Stip, E., Williams, R., MacEwan, G.W, Birmingham, C.L., & The Clozapine and Risperidone Enhancement Study Group. (2007). Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment. Journal of Psychiatry & Neuroscience : JPN, 32(5), 331-338.

Panenka, W. J., Khorram, B., Barr, A. M., Smith, G. N., Lang, D. J., Kopala, L. C., Vandorpe, R.A., & Honer, W. G. (2007). A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia. Schizophrenia Research, 94(1-3), 288-292.

Honer, W. G., Thornton, A. E., Sherwood, M., MacEwan, G. W., Ehmann, T. S., Williams, R., Kopala, L.C., & Barr, A. M. (2007). Conceptual and methodological issues in the design of clinical trials of antipsychotics for the treatment of schizophrenia. CNS Drugs, 21(9), 699-714.

Falkai, P., Honer, W. G., Kamer, T., Dustert, S., Vogeley, K., Schneider-Axmann, T., Dani, I., Wagner, M., Rietschel, M., Müller, D.J., Schulze, T.G., Gaebel, W., Cordes, J., Schönell, H., Schild, H.H., Block, W., Träber, F., Steinmetz, H., Maier, W., & Tepest, R. (2007). Disturbed frontal gyrification within families affected with schizophrenia. Journal of Psychiatric Research, 41(10), 805-813.

Austin J.C., & Honer W.G. (2007). The genomic era and serious mental illness: a potential application for psychiatric genetic counseling. Psychiatric Services, 58(2), 254-261.

Smith, G. N., Boydell, J., Murray, R. M., Flynn, S., McKay, K., Sherwood, M., & Honer, W. G. (2006). The incidence of schizophrenia in european immigrants to canada. Schizophrenia Research, 87(1-3), 205-211.

Sherwood, M., Thornton, A. E., & Honer, W. G. (2006). A meta-analysis of profile and time-course of symptom change in acute schizophrenia treated with atypical antipsychotics. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 9(3), 357-366.

Lang, D. J., Khorram, B., Goghari, V. M., Kopala, L. C., Vandorpe, R. A., Rui, Q., Smith, G.N., & Honer, W. G. (2006). Reduced anterior internal capsule and thalamic volumes in first-episode psychosis. Schizophrenia Research, 87(1-3), 89-99.

Kopala, L. C., Good, K. P., Milliken, H., Buiteman, C., Woodley, H., Rui, Q., Whitehorn, D., Love, L., Balshaw, R., Kiss, I., & Honer, W. G. (2006). Treatment of a first episode of psychotic illness with quetiapine: An analysis of 2 year outcomes. Schizophrenia Research, 81(1), 29-39.

Khorram, B., Lang, D. J., Kopala, L. C., Vandorpe, R. A., Rui, Q., Goghari, V. M., Smith, G.N., & Honer, W. G. (2006). Reduced thalamic volume in patients with chronic schizophrenia after switching from typical antipsychotic medications to olanzapine. The American Journal of Psychiatry, 163(11), 2005-2007.

Honer, W. G., Thornton, A. E., Chen, E. Y., Chan, R. C., Wong, J. O., Bergmann, A., Falkai, P., Pomarol-Clotet, E., McKenna, P.J., Stip, E., Williams, R., MacEwan, G.W., Wasan, K., Procyshyn, R., & The Clozapine and Risperidone Enhancement (CARE) Study Group. (2006). Clozapine alone versus clozapine and risperidone with refractory schizophrenia. The New England Journal of Medicine, 354(5), 472-482.

Barr, A. M., Young, C. E., Phillips, A. G., & Honer, W. G. (2006). Selective effects of typical antipsychotic drugs on SNAP-25 and synaptophysin in the hippocampal trisynaptic pathway. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 9(4), 457-463.

Barr, A.M., Panenka, W.J., MacEwan, G.W., Thornton, A.E., Lang, D.J., Honer, W.G., & Lecomte, T. (2006). The need for speed: an update on methamphetamine addiction. Journal of psychiatry & neuroscience : JPN, 31(5), 301-31.

Austin, J. C., Smith, G. N., & Honer, W. G. (2006). The genomic era and perceptions of psychotic disorders: Genetic risk estimation, associations with reproductive decisions and views about predictive testing. American Journal of Medical Genetics.Part B, Neuropsychiatric Genetics : The Official Publication of the International Society of Psychiatric Genetics, 141B(8), 926-928.